2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2418):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-152802
    2’-O-(3-Azidopropyl)-5-azacytidine
    2’-O-(3-Azidopropyl)-5-azacytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2’-O-(3-Azidopropyl)-5-azacytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    2’-O-(3-Azidopropyl)-5-azacytidine
  • HY-154583
    3’,5’-Bis-O-benzoyl-2’-deoxy-2’-fluoro-β-D-arabinouridine
    3’,5’-Bis-O-benzoyl-2’-deoxy-2’-fluoro-β-D-arabinouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’,5’-Bis-O-benzoyl-2’-deoxy-2’-fluoro-β-D-arabinouridine
  • HY-178594
    5-Formyl-CTP
    5-Formyl-CTP is a monomeric raw material that can be used for nucleic acid synthesis.
    5-Formyl-CTP
  • HY-174081
    3'-P-dTTP
    3'-P-dTTP is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-P-dTTP
  • HY-171517
    2′-O-MOE-AMP
    2′-O-MOE-AMP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2′-O-MOE-AMP
  • HY-178639
    5-Azdio-UTP
    5-Azdio-UTP is a monomeric raw material that can be used for nucleic acid synthesis.
    5-Azdio-UTP
  • HY-178685
    Peracetylated GalNAc PEG linker-azide
    Peracetylated GalNAc PEG linker-azide is a monomeric raw material that can be used for nucleic acid synthesis.
    Peracetylated GalNAc PEG linker-azide
  • HY-W006395R
    1-Methylcytosine (Standard)
    		Chemical
    1-Methylcytosine is a methylated form of the DNA base cytosine and used as a nucleobase of hachimoji DNA, in which it pairs with Isoguanine.
    1-Methylcytosine (Standard)
  • HY-178620
    3'-O-Phthalimido-2'-dA
    3'-O-Phthalimido-2'-dA is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-O-Phthalimido-2'-dA
  • HY-178657
    DMTr-2'-F-dG(iBu)-3'-(D)-DPSE-phosphoramidite
    DMTr-2'-F-dG(iBu)-3'-(D)-DPSE-Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-F-dG(iBu)-3'-(D)-DPSE-phosphoramidite
  • HY-178610
    2',3'-Dideoxy-C(Ac)
    2',3'-Dideoxy-C(Ac) is a monomeric raw material that can be used for nucleic acid synthesis.
    2',3'-Dideoxy-C(Ac)
  • HY-137695A
    ddGTPαS tetrasodium
    ddGTPαS tetrasodium, a nucleotide analog, can be used for chain extension in PCR assays.
    ddGTPαS tetrasodium
  • HY-123055R
    Adenosine dialdehyde (Standard)
    Adenosine dialdehyde (Standard) is the analytical standard of Adenosine dialdehyde. This product is intended for research and analytical applications. Adenosine dialdehyde, a purine nucleoside analogue, is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research.
    Adenosine dialdehyde (Standard)
  • HY-179540
    5-Bromo-UTP trisodium
    5-Bromo-UTP (5-BrUTP) trisodium is a derivative of uridine triphosphate (UTP). 5-Bromo-UTP trisodium can be utilized by cells as a precursor for RNA synthesis. During transcription, it integrates into the newly synthesized RNA chain and replaces some UTP. 5-Bromo-UTP trisodium can be used to label newly synthesized RNA, thereby enabling high-resolution visualization of transcriptional sites and RNA transport.
    5-Bromo-UTP trisodium
  • HY-137697A
    ddCTP tetrasodium
    ddCTP tetrasodium is a type of chain-terminating deoxynucleotide. ddCTP tetrasodium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP tetrasodium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP tetrasodium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication.
    ddCTP tetrasodium
  • HY-178668
    2'-O-MOE-rC(Ac)
    2'-O-MOE-rC(Ac) is a monomeric raw material that can be used for nucleic acid synthesis.
    2'-O-MOE-rC(Ac)
  • HY-178530
    N6-Methyl-dATP
    N6-Methyl-dATP is a monomeric raw material that can be used for nucleic acid synthesis.
    N6-Methyl-dATP
  • HY-W113972
    2'-F-iBu-G
    2'-F-iBu-G (2′-Deoxy-2′-fluoro-N-isobutyrylguanosine) is a nucleoside analog that can be used to synthesize oligoribonucleotides.
    2'-F-iBu-G
  • HY-178590
    3'-O-Phthalimido-2'-dG
    3'-O-Phthalimido-2'-dG is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-O-Phthalimido-2'-dG
  • HY-W881464
    DMTr-2'-O-Me-pseudoU-3'-CE-phosphoramidite
    DMTr-2'-O-Me-PseudoU-3'-CE-Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-Me-pseudoU-3'-CE-phosphoramidite